Gonadorelin
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Quick Details:
Product name: Gonadorelin
Synonyms: GnRH; Gonadotropin-Releasing Hormone; LHRH; Luliberin; Luteinizing Hormone-Releasing Factor
Unit size: 2 mg/vial & 10mg/vial
Cas No: 71447-49-9
Sequence: p-Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 acetate salt
Purity: ≥99% (HPLC)
Physical State: Lyophilized Powder
Solubility: Soluble in water or 1% acetic acid
Usage: Gonadorelin, also known as GnRH or LHRH, is produced by neuroendocrine cells within the hypothalamus. The hormone is secreted pulsatilely. Gonadorelin induces the release of LH and FSH from the anterior pituitary. After a transient increase, continuous administration of gonadorelin results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.
Applications:
Mainly has a strong angiotensin II vasoconstriction and increase in blood pressure. The mechanism is:
1. So that the body arteriole smooth muscle contraction, increased peripheral resistance;
2. So increase the release of adrenal aldosterone, causing sodium retention, increased blood volume;
3. Directly contribute to renal tubular sodium and water reabsorption;
4. So the brain central nervous sympathetic vasoconstrictor activity, causing increased peripheral vascular resistance;
5. Stimulate the adrenal medulla to release epinephrine and norepinephrine
